先进高分子材料研究所>>

侯信 教授

Email: houxin@tju.edu.cn

研究所:先进高分子材料研究所

天津市优秀科技特派员

个人简历

教育背景:

· 1987.8-1991.7,南开大学,化学系,学士

· 1991.9-1993.12,南大大学,高分子化学与物理,硕士

· 1994.9-1997.7,南开大学,高分子化学与物理,博士

工作经历:

· 2000.6-2002.6,天津大学,博士后

· 2008.8-2008.12,Virigina commonwealth University,化学与生物医药工程学院,访问学者

· 2012.3-2012.9,Floride State University,生命与工程学院,访问学者

· 2002.7-2013.6,天津大学,材料科学与工程学院,副教授

· 2013.6-至今,天津大学,材料科学与工程学院,教授

研究方向

· 研究领域

肿瘤靶向外泌体的共投递,药物辅料设计与合成,高分子复合材料

· 讲授课程:

航空复合材料,高分子基复合材料

承担项目

1.“多肽修饰的功能化外泌体共投递系统和对肿瘤的抑制研究”,天津市面上项目,2018~2021。

2.“肿瘤靶向外泌体的工程化构建及共投递microRNA/吉非替尼抑制分子靶向治疗耐药研究”,国家基金面上项目,2017~2020。

3.“煤矿充填用高分子材料研究”,校企横向合作项目,2015~2016。

4.“相选择性凝胶组装和凝胶化效应研究”,天津市面上项目,2014~2015。

5.“新型含硫,硒螺噁嗪类光致变色材料合成和应用研究”,国家基金面上项目,2012~2013。

6.“新型有机光电材料的研究与开发”,校企横向合作项目,2010~2012。

7. “新型复合功能高分子材料的研制和开发”,校企横向合作项目,2010~2012。

8.“新型自粘防水卷材改性研究”,校企横向合作项目,2010。

9.“镀锌钢材表面装饰漆的优化及性能研究”,校企横向合作项目,2007。

标志性成果

· 近期主要文章:

1. Qi Zhan, Kaikai Yi, Hongzhao Qi, Sidi Li, Xueping Li, Qixue Wang, Yunfei Wang, Chaoyong Liu, Mingzhe Qiu, Xubo Yuan, Jin Zhao*,Xin Hou*, Chunsheng Kang*, Engineering blood exosomes for tumor-targeting efficient gene/chemo combination therapy. Theranostics,2020, doi:10.7150/thno.45028. IF=8.063, TOP期刊

2. Hongzhao Qi,Chaoyong Liu,Lixia Long,Yu Ren,Shanshan Zhang,Xiaodan Chang,Xiaomin Qian,Huanhuan Jia,Jin Zhao, Jinjin Sun , Xin Hou*,Xubo Yuan,Chunsheng Kang. Blood Exosomes Endowed with Magnetic and Targeting Properties for Cancer Therapy. ACS nano, 2016, 10(3): 3323-3333.IF=13.903, TOP 期刊

3.Sidi Li, Ning Chen, Xueping Li, Yang Li, Zhipeng Xie, Zhenyu Ma, Jin Zhao*,Xin Hou, Xubo Yuan. Bioinspired Double-Dynamic-Bond Crosslinked Bioadhesive Enables Post-Wound Closure Care. Advanced Functional Materials,2020, 30(17): 2000130.IF=15.621, TOP期刊

4. Sidi Li, Luyang Chen, Kai Huang, Ning Chen, Qi Zhan, Kaikai Yi, Hongzhao Qi, Chaoyong Liu, Yanli Tan,Xin Hou, Yunfeng Lu, Jin Zhao*, Xubo Yuan*, Chunsheng Kang*. Tumor Microenvironment‐Tailored Weakly Cell‐Interacted Extracellular Delivery Platform Enables Precise Antibody Release and Function. Advanced Functional Materials,2019: 1903296.IF=15.621, TOP期刊

5. Yang Lijun, Han Donglin, Zhan Qi, Li Xueping, Zhao Jin,Hou Xin, Yuan Xubo*, Qi Hongzhao*,Blood TfR plus exosomes separated by a pH-responsive method deliver chemotherapeutics for tumor therapy, Theranostics, 2019,9(25):7680-7696 IF=8.063, TOP期刊

6. Zhou Yuehua,Yan Yufang,Du Yang,Chen Jie,Hou Xin*,Meng Jiben. Preparation and Application of Melamine-Formaldehyde Photochromic Microcapsules. Sensors and Actuators B: Chemical,2013, 188: 502-512.IF=6.393,TOP期刊

7. Hongzhao Qi, Lijun Yang, Xueping Li, Qi Zhan, Donglin Han, Jin Zhao*,Xin Hou*, Xubo Yuan*. Exosomes Separated Based on the “STOP” Criteria for Tumor-Targeted Drug Delivery. Journal of Materials Chemistry B,2018, 6(18): 2758-2768.IF=5.047

8. Ying Du,Xin Hou*, Jin Zhao*, Xubo Yuan. Effect of Neutralization on Physicochemical/Mechanical Properties of Hydroxypropylmethylcellulose Acetate Succinate. Materials Chemistry and Physics,2020, 249: 122963.IF=2.781

9. Cailing Zhuan, Yun Li, Xubo Yuan, Jin Zhao*,Xin Hou*.A Sorbitol-Based Phase-Selective Organogelator for Crude Oil Spills Treatment. Journal of Applied Polymer Science,2019, 136(6): 47052. IF=2.188

10. Li Yun, Jin Zhao*, Xiaoling Kang, Yang Du, Xubo Yuan,Xin Hou*. Preparation and Properties of Monolithic and Hydrophobic Gelatin-Silica Composite Aerogels for Oil Absorption. Journal of Sol-Gel Science and Technology,2017, 83(1): 197-206. IF=1.986

11. Hongzhao Qi, Lijun Yang, Xueping Li, Xiaolei Sun, Jin Zhao,Xin Hou, Zhaoyang Li, Xubo Yuan*, Zhenduo Cui, Xianjin Yang*. Systemic Administration of Enzyme-Responsive Growth Factor Nanocapsules for Promoting Bone Repair. Biomaterials science,2019, 7(4): 1675-1685. IF=5.251

12. Donglin Han, Hongzhao Qi, Kai Huang, Xueping Li, Qi Zhan, Jin Zhao,Xin Hou, Xianjin Yang, Chunsheng Kang*, Xubo Yuan*. The Effects of Surface Charge on the Intra-Tumor Penetration of Drug DeliveryVehicles with Tumor Progression. Journal of Materials Chemistry B,2018, 6(20): 3331-3339. IF=5.047

13.Sidi Li, Ning Chen, Yang Li, Xueping Li, Qi Zhan, Jiamin Ban, Jin Zhao*,Xin Hou, Xubo Yuan. Metal-crosslinked ?-poly-L-lysine Tissue Adhesives with High Adhesive Performance: Inspiration from Mussel Adhesive Environment. International Journal of Biological Macromolecules,2020, 153: 1251-1261.IF=4.784

14. Sidi Li, Ning Chen, Yang Li, Jin Zhao*,Xin Hou, Xubo Yuan. Environment-Dependent Adhesive Behaviors of Mussel-Inspired Coordinate-Crosslinked Bioadhesives. Macromolecular Materials and Engineering,2020, 305(1): 1900620.IF=3.038

· 代表性专利:

1.侯信,陈宁,李思迪,亓洪昭,韩冬琳,原续波,赵瑾,一种规模化合成蛋白纳米微囊的装置,中国,201721673846.7(已授权)

2.侯信,闫玉芳,尚跃再,京尼平交联弹性蛋白水凝胶的制备方法,2015.9.9中国,ZL201510137851.5(已授权)

3.侯信,闫玉芳,尚跃再,弹性蛋白水凝胶及其制备方法,中国,ZL201310294656.4(已授权)

4.侯信,程高平,张喆,汪洪,通过改变交联剂的配比对天然橡胶进行硫化改性方法及其产物,2013.6.5,中国,ZL201110247588.7(已授权)

5.侯信,陈杰,杜洋,一种微孔离子化高吸油树脂及其制备方法,中国,ZL201510216748.X(已授权)

· 代表性著作:

《材料科学基础》,靳正国,郭瑞松,侯信,师春生,天津大学出版社,2015.